Protein-Protein Interactions as New Drug Targets
K. L. Dodge-Kafka, A. Bauman, M. S. Kapiloff (auth.), Dr. Enno Klussmann, John Scott Ph.D. (eds.)Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions.
This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.
年:
2008
出版:
1
出版社:
Springer-Verlag Berlin Heidelberg
语言:
english
页:
512
ISBN 10:
3540728430
ISBN 13:
9783540728436
系列:
Handbook of Experimental Pharmacology 186
文件:
PDF, 4.05 MB
IPFS:
,
english, 2008
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